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Gautam, Hemendra
- Stability Indicating Absorption Ratio Method for Determination of Domperidone and Esomeprazole Magnesium in Capsule Dosage Form Using UV-Spectrophotometer
Authors
1 Department of Pharmaceutical Chemistry, Invertis Institute of Pharmacy, Invertis University, Bareilly (U.P.)
Source
Asian Journal of Research in Chemistry, Vol 6, No 8 (2013), Pagination: 735-739Abstract
A new stability indicating absorption ratio method was developed and validated for the determination of Esomeprazole magnesium (ESO) and Domperidone (DOM) in capsule dosage form. The maximum wavelength (λ max) was found to be 299nm for ESO and 287nm for DOM. The iso-absorptive point of both the drug was found to be 290 nm. The linearity range was found to be 1-6 μg ml<SUP>-1</SUP>(r<SUP>2</SUP>= 0.998) and 5-30 µg ml<SUP>-1</SUP>(r<SUP>2</SUP>= 0.999) for ESO and DOM respectively. The value of limit of detection and limit of quantification was 0.116µgml<SUP>-1</SUP> and 0.386µgml-1 for ESO and 0.657µgml<SUP>-1</SUP> and 2.18µgml<SUP>-1</SUP> for DOM respectively. Forced degradations were carried out under acid, base, thermal, photolytic and oxidative stress conditions. The method was satisfactorily validated as per ICH guideline. The result of study showed that the proposed spectrophotometric method is useful for the routine determination of ESO and DOM in its combined pharmaceutical dosage form.Keywords
Esomeprazole Magnesium, Domperidone, Spectrophotometric Method, Forced Degradation Studies, Absorption Ratio MethodReferences
- Scott LJ, Dunn CJ, Mallarkey G, Sharpe M. Esomeprazole – A review of its use in the management of acid-related disorders. Indian Drugs 62:1503-38.
- Sean C Sweetman. Martindale-The completer drug reference. 2002. pp. 1225.
- Trivedi PD, Maheswari DG. Estimation of Esomeprazole and Domperidone by absorption ratio method in Pharmaceutical Dosage form. International Journal of Chemical and Technological Research. 2(3); 2010: 1598-1605.
- Press, Budavari S. The Merck Index. 2010. pp. 3476.
- Anonymous (2007) Indian pharmacopoeia (IP), Indian pharmacopoeia commission, Ghaziabad, India, pp. 426-427.
- Anonymous (2007) The United States Pharmacopeial Convention (29th Edn), Rockville, MD, pp 2298.
- Anonymous (2003) stability testing of new drug substances, product Q1A (R2) International Conference on Hormonization, IFPMA Geneva.
- Bakshi M, Singh S. Development of validated stability indicating assay method- critical review. Journal of Pharmaceutical and Biomedical Analysis. 28; 2002: 1011-1040.
- Solanki S, Captain D, Patel BV. Simultaneous determination of domperidone and esomeprazole magnesium in pharmaceutical capsule formulation by derivative spectrophotometric method. International Journal of Chemical and Technological Research. 3(4); 2011:1747-1750
- Singh S, Dubey N, Jain DK. Simultaneous estimation of atorvastatin, clopidogrel and aspirin in capsule dosage form using UV-Spectroscopy. Asian Journal of Research in Chemistry. 3(4); 2010: 885-887.
- Singh S, Yadav AK, Gautam H. Simultaneous estimation of valsartan and hydrochlorothiazide in solid dosage form using UV- Spectroscopy. Bulletin of Pharmaceutical Research. 1(3); 2011: 10-12.
- Patel K, Singh S, Sahu p, Trivedi P. Development and validation of stability indicating assay method for naratriptan by ultra performance liquid chromatography. Scholar Research Library. 3(6): 102-107.
- Singh S, Dubey N, Jain DK. Simultaneous estimation of cefpodoxime proxetil and clavulate potassium combined dosage form using UV-Spectroscopy and reverse phase liquid chromatography. International Journal of Pharmaceutical and Biomedical Science. 5(1); 2011: 57-60.
- Singh S, Yadav AK, Gautam H. First Order Derivative Spectrophotometric Determination of Telmisartan in Pharmaceutical Formulation. Bulletin of Pharmaceutical Research. 2(2); 2012: 83-86.
- Singh S, Patel K, Agarwal VK, Chaturvedi S. Simultaneous estimation of S(-) Amlodipine Besylate Hemipentahydrate and Losartan Potassium in Combined Dosage Form by Using UVSpectroscopy. Scholar Research Library. 4(3); 2002: 897-905.
- Singh S, Patel K, Agarwal VK, Chaturvedi S. Stability Indicating HPTLC Method for Simultaneous Determination of Valsartan and Hydrochlorothiazide in Tablets. International Journal of Pharmaceutical and Pharma. Science. 4(4); 2012: 468-471.
- Singh S, Inamullah, Rai J, Choudhary N, Sharma S. Stability Indicating UV-VIZ specrophotometeric method for estimation of atorvastatin calcium and fenofibrate in tablet dosage form. Bulletin of Pharmaceutical Research. 2(3); 2012: 159-166.
- Phytochemical Analysis of Leaves of Hibiscus rosa-sinensis
Authors
1 Department of Pharmacology, Invertis Institute of Pharmacy, Invertis University, Bareilly, IN
2 Department of Pharmacology, Invertis Institute of Pharmacy, Invertis University, Bareilly, IN
3 Department of Pharmaceutical Chemistry, Invertis Institute of Pharmacy, Invertis University, Bareilly, IN
4 Department of Pharmacognosy, Invertis Institute of Pharmacy, Invertis University, Bareilly, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 5, No 4 (2013), Pagination: 182-184Abstract
Ethnopharmacological relevance
Medicinal plants play a vital role for the development of new drugs. The extracts of Hibiscus rosa-sinensis and the crude drug itself are being used as an anti-ulcer, aphrodisiac, menorrhagic, oral contraceptive, laxative, antifertility, anti-implantation, abortifacient, epilepsy, leprosy, bronchial catarrh and diabetes.
Aim of the study
To establish authenticity, possible to help and distinguish the drug from other species by preliminary pharmacognostical screening of Hibiscus rosasinensis leaves
Material and methods
The plant was extracted with different solvents and the extracts were subjected to different qualitative chemical tests.
Results
The presence of various phytoconstituents was observed during the test such as glycosides, alkaloids, tannins, flavonoids, saponin and carbohydrates were present in the extracts.
Conclusion
We believe that The investigation carried out by us led to certain findings about the phytochemical features which no doubt can be proved beneficial and serve as scientific background for further isolation steps to obtain the lead compound.